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\/>\n\u3000\u6708\u7d4c\u75db\u306e\u91cd\u3044\u50be\u5411\u306e\u4eba\u3068\u8efd\u3044\u50be\u5411\u306e\u4eba\u3068\u3067\u7570\u306a\u308b\u907a\u4f1d\u578b\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u30011\u756a\u67d3\u8272\u4f53\u306eNGF\u304a\u3088\u30732\u756a\u67d3\u8272\u4f53\u306eIL1A\u3068\u547c\u3070\u308c\u308b\u907a\u4f1d\u5b50\u9818\u57df\u306b\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002NGF\u306f\u795e\u7d4c\u306e\u6210\u9577\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u3068\u3057\u3066\u3088\u304f\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u904e\u53bb\u306e\u7814\u7a76\u3067\u3082\u6708\u7d4c\u56f0\u96e3\u75c7\u306b\u304a\u3051\u308b\u75db\u307f\u306e\u5f37\u3055\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001IL1A\u306f\u75db\u307f\u3084\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3001\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3\uff08\u5b50\u5bae\u3092\u53ce\u7e2e\u3055\u305b\u9663\u75db\u3092\u5f15\u304d\u8d77\u3053\u3059\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308a\u3001\u6708\u7d4c\u75db\u306e\u4e3b\u306a\u539f\u56e0\u3068\u8a00\u308f\u308c\u3066\u3044\u308b\uff09\u306e\u751f\u7523\u3092\u4fc3\u3059\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u66f4\u306b\u3001IL1A\u306f\u5b50\u5bae\u5185\u819c\u75c7\u3068\u95a2\u9023\u304c\u5f37\u3044\u3053\u3068\u3082\u904e\u53bb\u306e\u7814\u7a76\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u56f32\uff09\u3002<strong>\u3010\u6708\u7d4c\u4e2d\u306e\u767a\u71b1\u3011<\/strong><br \/>\n\u3000\u3055\u3089\u306b\u3001\u30a2\u30f3\u30b1\u30fc\u30c8\u3067\u6708\u7d4c\u4e2d\u306b\u3042\u308b\u75c7\u72b6\u3068\u3057\u3066\u300c\u767a\u71b1\u300d\u3092\u9078\u3093\u3060\u4eba\u306b\u304a\u3044\u3066\u306f\u30016\u756a\u67d3\u8272\u4f53\u306eOPRM1\u3068\u547c\u3070\u308c\u308b\u907a\u4f1d\u5b50\u9818\u57df\u306b\u7279\u5fb4\u7684\u306a\u907a\u4f1d\u578b\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u4e00\u3064\u3067\u3042\u308b\u03b2-\u30a8\u30f3\u30c9\u30eb\u30d5\u30a3\u30f3\u306e\u53d7\u5bb9\u4f53\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u52d5\u7269\u5b9f\u9a13\u306b\u304a\u3044\u3066\u03b2-\u30a8\u30f3\u30c9\u30eb\u30d5\u30a3\u30f3\u304c\u4f53\u6e29\u306e\u8abf\u7bc0\u306b\u95a2\u308f\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u4eba\u9593\u306b\u304a\u3044\u3066\u3082\u767a\u71b1\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\uff08\u56f33\uff09\u3002\u3000\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u591a\u578b\u304c\u3001\u5b9f\u969b\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306b\u4e0e\u3048\u308b\u91cf\u7684\u52b9\u679c\u3092eQTL\uff08expression quantitative trait loci\u3001\u6ce83\uff09\u3068\u8a00\u3044\u307e\u3059\u3002eQTL\u89e3\u6790\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u907a\u4f1d\u5b50\u591a\u578b\u3068\u300c\u75be\u60a3\u767a\u75c7\u3084\u4f53\u8cea\u300d\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306eGWAS\u3067\u5f97\u3089\u308c\u305f\u6210\u679c\u3068\u6700\u8fd1\u306eGTEx Portal\uff08\u6ce84\uff09\u306e\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u3067\u306eeQTL\u306e\u5171\u5c40\u5728\u89e3\u6790\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u6211\u3005\u306e\u540c\u5b9a\u3057\u305fSNPs\u304c\u3001\u5b9f\u969b\u306b\u30bf\u30f3\u30d1\u30af\u767a\u73fe\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3084\u30ed\u30f3\u30b0\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u306e\u767a\u73fe\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u3000\u4eca\u5f8c\u306f\u672c\u7814\u7a76\u306b\u3066\u5f97\u3089\u308c\u305f\u7d50\u679c\u3092\u3082\u3068\u306b\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u3092\u9032\u3081\u907a\u4f1d\u56e0\u5b50\u304a\u3088\u3073\u74b0\u5883\u56e0\u5b50\u306e\u5168\u8c8c\u304c\u660e\u3089\u304b\u306b\u306a\u308b\u3053\u3068\u3067\u3001\u500b\u4eba\u306e\u4f53\u8cea\u306b\u5408\u308f\u305b\u305f\u6708\u7d4c\u4e2d\u306e\u75db\u307f\u3084\u767a\u71b1\u306a\u3069\u306e\u6539\u5584\u306e\u53d6\u308a\u7d44\u307f\u3001\u3055\u3089\u306b\u306f\u5b50\u5bae\u5185\u819c\u75c7\u3001\u4e73\u304c\u3093\u306a\u3069\u306e\u5973\u6027\u7279\u6709\u306e\u75be\u60a3\u3068\u4f53\u8cea\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u89e3\u6790\u3057\u3001\u4e00\u4eba\u3072\u3068\u308a\u306b\u5408\u3063\u305f\u60c5\u5831\u3084\u30a2\u30c9\u30d0\u30a4\u30b9\u306e\u63d0\u4f9b\u3001\u4e88\u9632\u6cd5\u306e\u9078\u629e\u304c\u53ef\u80fd\u306b\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<strong>5.\u767a\u8868\u96d1\u8a8c\uff1a<\/strong><br \/>\n\u25cf\u96d1\u8a8c\u540d\uff1a\u300cScientific Reports\u300d\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\uff1a5\u670831\u65e5\uff09<br \/>\n\u25cf\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1aJapanese GWAS identifies variants for bust-size, dysmenorrhea, and menstrual fever that are eQTLs for relevant protein-coding or long non-coding RNAs.<br \/>\n\u25cf\u8457\u8005\uff1aTetsuya Hirata1,\u00b6, Kaori Koga1,\u00b6, <strong>Todd A. Johnson2,\u00b6, <\/strong>Ryoko Morino3, Kazuyuki Nakazono2, Shigeo Kamitsuji2, Masanori Akita3, Maiko Kawajiri3, Azusa Kami3, Yuria Hoshi4, Asami Tada3, Kenichi Ishikawa3, Maaya Hine5, Miki Kobayashi5, Nami Kurume5, Tomoyuki Fujii1, Naoyuki Kamatani2, and<strong> Yutaka Osuga1,*<\/strong><br \/>\n1Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan<br \/>\n2StaGen Co., Ltd., Taito-ku, Tokyo, 111-0051, Japan<br \/>\n3EverGene Ltd., Shinjuku-ku, Tokyo, 163-1435, Japan<br \/>\n4Life Science Group, Healthcare Division, Department of Healthcare Business, MTI Ltd., Shinjuku-ku, Tokyo, 163-1435, Japan<br \/>\n5LunaLuna Division, Department of Healthcare Business, MTI Ltd., Shinjuku-ku, Tokyo, 163-1435, Japan<br \/>\nDOI\u756a\u53f7\uff1a10.1038\/s41598-018-25065-9<br \/>\n\u30a2\u30d6\u30b9\u30c8\u30e9\u30af\u30c8URL\uff1ahttps:\/\/www.nature.com\/articles\/s41598-018-25065-9<strong>6.\u554f\u3044\u5408\u308f\u305b\u5148\uff1a<\/strong><br \/>\n\u226a\u7814\u7a76\u306b\u95a2\u3059\u308b\u304a\u554f\u3044\u5408\u308f\u305b\u226b<br \/>\n\u6771\u4eac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\u3000\u5973\u6027\u5916\u79d1<br \/>\n\u8b1b\u5e2b\u3000\u5e73\u7530\u3000\u54f2\u4e5f\u3000\uff08\u3072\u3089\u305f\u3000\u3066\u3064\u3084\uff09<br \/>\n\u96fb\u8a71\uff1a03-5800-8657\u3000\u3000E-mail\uff1a<a class=\"blue\" href=\"mailto:thira-tky@umin.ac.jp\">thira-tky@umin.ac.jp<\/a>\u226a\u5e83\u5831\u62c5\u5f53\u8005\u9023\u7d61\u5148\u226b<br \/>\n\u6771\u4eac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u30d1\u30d6\u30ea\u30c3\u30af\u30fb\u30ea\u30ec\u30fc\u30b7\u30e7\u30f3\u30bb\u30f3\u30bf\u30fc \uff08\u62c5\u5f53\uff1a\u6e21\u90e8\u3001\u5c0f\u5ca9\u4e95\uff09<br \/>\n\u96fb\u8a71\uff1a03-5800-9188\uff08\u76f4\u901a\uff09\u3000\u3000E-mail\uff1a<a class=\"blue\" href=\"mailto:pr@adm.h.u-tokyo.ac.jp\">pr@adm.h.u-tokyo.ac.jp<\/a><br \/>\n\u682a\u5f0f\u4f1a\u793e\u30a8\u30e0\u30c6\u30a3\u30fc\u30a2\u30a4\u3000\u5e83\u5831\u5ba4<br \/>\n\u96fb\u8a71\uff1a03-5333-6323\u3000\u3000FAX\uff1a03-3320-0189<br \/>\nE-mail\uff1a<a class=\"blue\" href=\"mailto:mtipr@mti.co.jp\">mtipr@mti.co.jp<\/a>\u3000\u3000URL\uff1a<a class=\"blue\" href=\"http:\/\/www.mti.co.jp\">http:\/\/www.mti.co.jp<\/a><strong>7.\u7528\u8a9e\u89e3\u8aac\u5148\uff1a<\/strong><br \/>\n\uff08\u6ce81\uff09GWAS\uff1a\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\u3002\u5168\u30b2\u30ce\u30e0\u4e0a\u306e\u907a\u4f1d\u5b50\u30de\u30fc\u30ab\u30fc\uff08SNP\u306a\u3069\uff09\u3092\u7db2\u7f85\u7684\u306b\u8abf\u3079\u3001\u8868\u73fe\u578b\uff08\u75be\u60a3\u3084\u4f53\u8cea\u306a\u3069\u306e\u7279\u5fb4\uff09\u3068\u306e\u95a2\u9023\u306e\u5f37\u3055\u3092\u89e3\u6790\u3059\u308b\u7d71\u8a08\u7684\u624b\u6cd5\u3002<br \/>\n\uff08\u6ce82\uff09SNP\uff1a\u5358\u5869\u57fa\u591a\u578b\u3002\u7d0430\u5104\u306e\u30d2\u30c8\u30b2\u30ce\u30e0\u306e\u4e2d\u306e1\u7b87\u6240\u306e\u500b\u4eba\u3054\u3068\u306e\u9055\u3044\u3002<br \/>\n\uff08\u6ce83\uff09eQTL (expression Quantitative Trait Locus)\uff1a\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u91cf\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u5ea7\u4f4d\u3002<br \/>\n\uff08\u6ce84\uff09GTEx (Genotype-Tissue 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