{"id":22411,"date":"2018-01-19T11:00:44","date_gmt":"2018-01-19T02:00:44","guid":{"rendered":"http:\/\/www.mti.co.jp\/?p=22411"},"modified":"2023-05-11T14:28:12","modified_gmt":"2023-05-11T05:28:12","slug":"%e3%80%8e%e3%83%ab%e3%83%8a%e3%83%ab%e3%83%8a%e3%80%8f%e3%83%a6%e3%83%bc%e3%82%b6%e3%83%bc%e7%b4%841%e4%b8%87%e4%ba%ba%e3%81%ae%e9%81%ba%e4%bc%9d%e5%ad%90%e6%83%85%e5%a0%b1%e3%82%92%e3%82%82%e3%81%a8","status":"publish","type":"post","link":"https:\/\/www.mti.co.jp\/?p=22411","title":{"rendered":"\u300e\u30eb\u30ca\u30eb\u30ca\u300f\u30e6\u30fc\u30b6\u30fc\u7d041\u4e07\u4eba\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u3082\u3068\u306b\u3001\u30a8\u30d3\u3068\u30e2\u30e2\u306e\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u95a2\u9023\u306e\u5f37\u3044\u907a\u4f1d\u5b50\u9818\u57df\u3092\u65b0\u305f\u306b\u767a\u898b\uff01"},"content":{"rendered":"

\u3000\uff08\u682a\uff09\u30a8\u30e0\u30c6\u30a3\u30fc\u30a2\u30a4\uff08\u4ee5\u4e0b\u3001\u5f53\u793e\uff09\u304c\u904b\u55b6\u3059\u308b\u3001\u5973\u6027\u306e\u5065\u5eb7\u60c5\u5831\u30b5\u30fc\u30d3\u30b9\u300e\u30eb\u30ca\u30eb\u30ca\u300f\u3068\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u30b5\u30fc\u30d3\u30b9\u3092\u624b\u639b\u3051\u308b\u5f53\u793e100%\u5b50\u4f1a\u793e\u306e\uff08\u682a\uff09\u30a8\u30d0\u30fc\u30b8\u30fc\u30f3\u306f\u30012014\u5e74\u304b\u3089\u201c\u533b\u7642\u6cd5\u4eba\u793e\u56e3 \u85ac\u5584\u4f1a \u3064\u304f\u3070\u56fd\u969b\u81e8\u5e8a\u85ac\u7406\u30af\u30ea\u30cb\u30c3\u30af\u201d\u306e\u9662\u9577\u3067\u3042\u308a\u3001\uff08\u682a\uff09\u30b9\u30bf\u30fc\u30b8\u30a7\u30f3\u306e\u4f1a\u9577\u3082\u52d9\u3081\u308b\u938c\u8c37\u76f4\u4e4b\u535a\u58eb\u3068\u5171\u540c\u3067\u3001\u5973\u6027\u306b\u7279\u5316\u3057\u305f\u907a\u4f1d\u5b50\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002
\n\u3000\u672c\u7814\u7a76\u306f\u3001\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u306e\u30a2\u30c9\u30d0\u30a4\u30b9\u306e\u3082\u3068\u3001\u300e\u30eb\u30ca\u30eb\u30ca\u300f\u30e6\u30fc\u30b6\u30fc\u306e\u5354\u529b\u800511,011\u4eba\u306e\u907a\u4f1d\u5b50\u89e3\u6790\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u89e3\u6790\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u30a8\u30d3\u3068\u30e2\u30e2\u306e\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u95a2\u9023\u306e\u5f37\u3044\u907a\u4f1d\u5b50\u9818\u57df\u3092\u65b0\u305f\u306b\u767a\u898b\u3057\u307e\u3057\u305f\u3002
\n\u3000\u306a\u304a\u3001\u672c\u7814\u7a76\u7d50\u679c\uff08Genome-wide association study of self-reported food reactions in Japanese identifies shrimp and peach specific loci in the HLA-DR\/DQ gene region\uff09\u306f\u3001\u300cScientific Reports\u96fb\u5b50\u7248\u300d\uff082018\u5e741\u670818\u65e5\u4ed8\u3051\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u25c6\u5973\u6027\u306e\u5065\u5eb7\u3067\u5e78\u305b\u306a\u6bce\u65e5\u3078\u306e\u8ca2\u732e\u3092\u76ee\u6307\u30572014\u5e74\u3088\u308a\u907a\u4f1d\u5b50\u7814\u7a76\u3092\u30b9\u30bf\u30fc\u30c8<\/strong>
\n\u30001,100\u4e07\u30a4\u30f3\u30b9\u30c8\u30fc\u30eb\u4ee5\u4e0a\u3092\u8a87\u308b\u5973\u6027\u306e\u5065\u5eb7\u60c5\u5831\u30b5\u30fc\u30d3\u30b9\u300e\u30eb\u30ca\u30eb\u30ca\u300f\u306f\u3001\u751f\u7406\u65e5\u7ba1\u7406\u3092\u306f\u3058\u3081\u598a\u5a20\u30fb\u51fa\u7523\u30fb\u80b2\u5150\u307e\u3067\u3001\u3042\u3089\u3086\u308b\u30e9\u30a4\u30d5\u30b9\u30c6\u30fc\u30b8\u306e\u5973\u6027\u306e\u5065\u5eb7\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u3066\u3044\u307e\u3059\u30022014\u5e74\u304b\u3089\u300e\u30eb\u30ca\u30eb\u30ca\u300f\u30e6\u30fc\u30b6\u30fc\u5354\u529b\u306e\u3082\u3068\u3001\u5f53\u793e100\uff05\u5b50\u4f1a\u793e\u3067\u3042\u308b\uff08\u682a\uff09\u30a8\u30d0\u30fc\u30b8\u30fc\u30f3\u306e\u907a\u4f1d\u5b50\u89e3\u6790\u30b5\u30fc\u30d3\u30b9\u3092\u5229\u7528\u3057\u3001\u533b\u7642\u6cd5\u4eba\u793e\u56e3 \u85ac\u5584\u4f1a \u3064\u304f\u3070\u56fd\u969b\u81e8\u5e8a\u85ac\u7406\u30af\u30ea\u30cb\u30c3\u30af\u306e\u9662\u9577\u3067\u3042\u308a\uff08\u682a\uff09\u30b9\u30bf\u30fc\u30b8\u30a7\u30f3\u306e\u4f1a\u9577\u3082\u52d9\u3081\u308b\u938c\u8c37\u76f4\u4e4b\u535a\u58eb\u3068\u3001\u5973\u6027\u304c\u3088\u308a\u5065\u5eb7\u3067\u8f1d\u304f\u793e\u4f1a\u306e\u5b9f\u73fe\u3092\u76ee\u6307\u3057\u3001\u5973\u6027\u306b\u7279\u5316\u3057\u305f\u907a\u4f1d\u5b50\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002
\n\u3000\u4eca\u56de\u3001\u305d\u306e\u7814\u7a76\u7d50\u679c\u306e\u7b2c1\u5f3e\u3068\u3057\u3066\u3001\u30a8\u30d3\u3068\u30e2\u30e2\u306e\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u95a2\u9023\u306e\u5f37\u3044\u907a\u4f1d\u5b50\u9818\u57df\u3092\u65b0\u305f\u306b\u767a\u898b\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u25c6\u30a8\u30d3\u3068\u30e2\u30e2\u306e\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306b\u95a2\u9023\u306e\u5f37\u3044\u907a\u4f1d\u5b50\u9818\u57df\u3092\u65b0\u305f\u306b\u7279\u5b9a<\/strong>
\n\u3000\u672c\u7814\u7a76\u306f\u3001\u300e\u30eb\u30ca\u30eb\u30ca\u300f\u30e6\u30fc\u30b6\u30fc\u306e\u5354\u529b\u8005\u7d042\u4e07\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u81ea\u5b85\u3067\u63a1\u53d6\u3057\u305f\u553e\u6db2\u3088\u308a\u62bd\u51fa\u3057\u305fDNA\u304b\u3089\u7d0460\u4e07SNP\u203b1\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u8aad\u307f\u53d6\u308a\u3001\u305d\u306e\u4e2d\u304b\u3089\u7cbe\u5ea6\u306e\u9ad8\u3044\u691c\u4f53\u304a\u3088\u3073SNP\u306e\u307f\u3092\u62bd\u51fa\u3057\u3066\u5f97\u305f11,011\u4eba\u3001\u7d0454\u4e07SNP\u306e\u907a\u4f1d\u60c5\u5831\u3068\u3001\u7279\u5b9a\u306e\u98df\u7269\u306b\u5bfe\u3057\u3066\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u306b\u95a2\u3059\u308bWEB\u30a2\u30f3\u30b1\u30fc\u30c8\u306e\u7d50\u679c\u3092\u7528\u3044\u3066\u3001\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u306e\u30a2\u30c9\u30d0\u30a4\u30b9\u306e\u3082\u3068\u7db2\u7f85\u7684\u306a\u89e3\u6790\uff08GWAS\u203b2\uff09\u3092\u884c\u3044\u3001\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u907a\u4f1d\u5b50\u3068\u306e\u95a2\u9023\u306e\u5f37\u3055\u3092\u8abf\u3079\u307e\u3057\u305f\u3002
\n\u3000\u305d\u306e\u7d50\u679c\u3001\u30a2\u30f3\u30b1\u30fc\u30c8\u306b\u3066\u30a8\u30d3\u304a\u3088\u3073\u30e2\u30e2\u306e\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u304c\u3042\u308b\u3068\u56de\u7b54\u3057\u305f\u691c\u4f53\u306b\u3001\u7279\u5fb4\u7684\u306a\u907a\u4f1d\u578b\u306e\u7d44\u307f\u5408\u308f\u305b\uff08\u907a\u4f1d\u7684\u591a\u578b\uff09\u304c6\u756a\u67d3\u8272\u4f53\u4e0a\u306b\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u5834\u6240\u306fHLA\u203b3\u3068\u547c\u3070\u308c\u308b\u9818\u57df\u3067\u3001\u30a8\u30d3\u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u30e2\u30e2\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u3001\u305d\u308c\u305e\u308c\u306b\u95a2\u308f\u308bHLA\u578b\u306e\u7d44\u307f\u5408\u308f\u305b\uff08HLA\u591a\u578b\uff09\u3082\u7279\u5b9a\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30a8\u30d3\u30a2\u30ec\u30eb\u30ae\u30fc\u306f\u30ab\u30cb\u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u3001\u30e2\u30e2\u30a2\u30ec\u30eb\u30ae\u30fc\u306f\u30ea\u30f3\u30b4\u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u3001\u305d\u308c\u305e\u308c\u5171\u901a\u306eHLA\u591a\u578b\u304c\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\"
\n\u226a\u67d3\u8272\u4f53\u306e1\u756a\u304b\u308922\u756a\u3001\u66f4\u306b\u306fX\u67d3\u8272\u4f53\u4e0a\u306e\u7d0454\u4e07\u500b\u306eSNP\u3092\u4e26\u3079\u3001\u30e2\u30e2\uff08\u4e0a\uff09\u3001\u30a8\u30d3\uff08\u4e0b\uff09\u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u306e\u95a2\u9023\u306e\u5f37\u3055\u3092\u793a\u3057\u305f\u56f3\u3002\u6a2a\u8ef8\u304c\u67d3\u8272\u4f53\u4e0a\u306e\u4f4d\u7f6e\u3001\u7e26\u8ef8\u304cSNP\u3068\u8868\u73fe\u578b\uff08\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\uff09\u3068\u306e\u95a2\u9023\u306e\u5f37\u3055\u3092\u793a\u3059\u226b<\/span>

\n\u3000\u4eca\u5f8c\u306f\u672c\u7814\u7a76\u7d50\u679c\u3092\u3082\u3068\u306b\u3001\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u65e9\u671f\u691c\u51fa\u306b\u7e4b\u304c\u308b\u65b0\u3057\u3044\u88fd\u54c1\u3084\u30b5\u30fc\u30d3\u30b9\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066\u3044\u304d\u307e\u3059\u3002

\n\u203b1 SNP\uff1a\u5358\u5869\u57fa\u591a\u578b\u3002\u7d0430\u5104\u306e\u30d2\u30c8\u30b2\u30ce\u30e0\u306e\u4e2d\u306e1\u7b87\u6240\u306e\u500b\u4eba\u3054\u3068\u306e\u9055\u3044\u3002
\n\u203b2 GWAS\uff1a\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\u3002\u5168\u30b2\u30ce\u30e0\u4e0a\u306e\u907a\u4f1d\u5b50\u30de\u30fc\u30ab\u30fc\uff08SNP\u306a\u3069\uff09\u3092\u7db2\u7f85\u7684\u306b\u8abf\u3079\u3001\u8868\u73fe\u578b\uff08\u75be\u60a3\u3084\u4f53\u8cea\u306a\u3069\u306e\u7279\u5fb4\uff09\u3068\u306e\u95a2\u9023\u306e\u5f37\u3055\u3092\u89e3\u6790\u3059\u308b\u7d71\u8a08\u7684\u624b\u6cd5\u3002
\n\u203b3 HLA\uff1a\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\u3002\u767d\u8840\u7403\u306e\u578b\u3092\u793a\u3059\u3082\u306e\u3068\u3057\u3066\u767a\u898b\u3055\u308c\u305f\u304c\u3001\u73fe\u5728\u3067\u306f\u767d\u8840\u7403\u3060\u3051\u3067\u306a\u304f\u30d2\u30c8\u306e\u307b\u307c\u3059\u3079\u3066\u306e\u7d30\u80de\u306b\u5206\u5e03\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304a\u308a\u3001\u514d\u75ab\u306b\u95a2\u308f\u308b\u91cd\u8981\u306a\u5206\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/span>

\n\u3010\u938c\u8c37\u76f4\u4e4b\u535a\u58eb\u304b\u3089\u306e\u30b3\u30e1\u30f3\u30c8\u3011<\/strong>
\n\u540c\u3058\u624b\u6cd5\u306b\u3088\u308a\u7c73\u56fd\u304b\u3089\u30d4\u30fc\u30ca\u30c3\u30c4\u30a2\u30ec\u30eb\u30ae\u30fc\u306b\u95a2\u9023\u3057\u305f\u907a\u4f1d\u5b50\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u30a8\u30d3\u3084\u30e2\u30e2\u306b\u95a2\u9023\u3057\u305f\u907a\u4f1d\u5b50\u304c\u3053\u306e\u3088\u3046\u306a\u81a8\u5927\u306a\u6570\u306e\u4eba\u3005\u3068\u81a8\u5927\u306a\u6570\u306e\u907a\u4f1d\u5b50\u304b\u3089\u5f97\u3089\u308c\u305f\u30c7\u30fc\u30bf\u3067\u8a3c\u660e\u3055\u308c\u305f\u306e\u306f\u521d\u3081\u3066\u3067\u3059\u3002
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